Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KSM4024 | KSM4024 | Kenya | 2000 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| T97A | K14R, A21T, V31I, D41N, L74I, T112V, I113V, T124A, T125A, V126F, G134N, K136Q, E157Q, K160Q, D167E, V201I, Q216H, Y227F, L234V | S283G |
| >KSM4024| codons 1-288 FLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVASCNKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIIIVAVHVASGYIEAEVIPAETGQEAAYFLLKLAGRWPVKVVHTDNGSN FTSAAFKAACWWANIQQEFGIPYNPQSQGVVESMNKQLKQIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKHITKIQNFRVYFRDSRDPVWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89M |
| >KSM4024| codons 1-99 PQITLWQRPLVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, V60I, K122E, D123N, I135T, K173A, Q174K, V179I, T200A, Q207A, R211N, K238R, E248Q, A272P, T286A, E291D, I293V, P294T, E312D, G335D, M357R, G359S, T369A, E370D, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435A, L452I, V458I, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S |
| >KSM4024| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLNWGFTTPDKKHQKEPPFLWMGYELHPDRWT VQPIVLPQKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HTNDVKQLADVVQKVVMESIVIWGKTPKFKLPIQKETWETWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIAGAETFYVDGAANRETKIGKAGYITDRGRQKVVSLTETTNQKTELH AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIGKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |