<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KNH1211 KNH1211 Kenya 2000 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    I5V, K14R, I72V, T112V, I113V, S119P, T122I, T124A, T125A, K136Q, D167E, V201I, T218I, L234I S283G
>KNH1211| codons 1-288
FLDGVDKAQEEHERYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGPN
FISAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, M36I, N37D, R41K, K45R, R57K, H69K, L89M  
>KNH1211| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDIDLPGKWKPRMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K11T, V35T, V60I, D121H, K122E, D123S, I135T, K173S, Q174K, V179I, G196E, Q207A, R211S, V245M, D250E, A272P, K275R, T286A, V292I, I293V, P294T, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386A, E396D, A400T, T403M, E404D, E432D, V435T, K465R, D471E, Q480H, L491S, Q507H, K512S, S519N, Q524K, K527E, E529D, V531I, A534S, A554S  
>KNH1211| codons 1-560
PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPDIII
YQYMDDLYVGSDLEIEQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTEIVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA
HTNDVKQLAEVVQKVVMESIVIWGKAPKFKLPIQKDTWETWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPITGAETFYVDGAANRETKLGKAGYVTDRGRQRVVSLTETTNQKTELH
AIHLALQDSGSEVNIVTDSQYALGIIHAQPDSSESELVNQIIEKLIEKDKIYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Dowling, WE Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS, 2002