Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KNH1211 | KNH1211 | Kenya | 2000 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| I5V, K14R, I72V, T112V, I113V, S119P, T122I, T124A, T125A, K136Q, D167E, V201I, T218I, L234I | S283G |
| >KNH1211| codons 1-288 FLDGVDKAQEEHERYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGPN FISAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, E35D, M36I, N37D, R41K, K45R, R57K, H69K, L89M |
| >KNH1211| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDIDLPGKWKPRMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11T, V35T, V60I, D121H, K122E, D123S, I135T, K173S, Q174K, V179I, G196E, Q207A, R211S, V245M, D250E, A272P, K275R, T286A, V292I, I293V, P294T, E312D, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, T386A, E396D, A400T, T403M, E404D, E432D, V435T, K465R, D471E, Q480H, L491S, Q507H, K512S, S519N, Q524K, K527E, E529D, V531I, A534S, A554S |
| >KNH1211| codons 1-560 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTEIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVKQLAEVVQKVVMESIVIWGKAPKFKLPIQKDTWETWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPITGAETFYVDGAANRETKLGKAGYVTDRGRQRVVSLTETTNQKTELH AIHLALQDSGSEVNIVTDSQYALGIIHAQPDSSESELVNQIIEKLIEKDKIYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |