<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KNH1209 KNH1209 Kenya 2000 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    L2I, E11D, K14R, A21T, V31I, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, L234V S283G
>KNH1209| codons 1-288
FIDGIDKAQEDHERYHSNWRTMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, K14R, E35D, M36I, N37D, R41K, R57K, H69K, K70R, L89M  
>KNH1209| codons 1-99
PQITLWQRPIVTVRIGGQLKEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K11E, V35T, K49R, V60I, D121H, D123S, I135T, T165I, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245Q, D250E, K275R, V276I, T286A, E291D, V292I, I293V, P294T, E312N, I326V, G335E, M357K, G359S, A360T, T369A, A371V, I375V, T377M, A400T, T403M, E404D, Y405H, E432D, V435M, E449Q, T470P, D471E, Q480Y, L491S, K512R, L517I, S519N, K527E, E529D, K530R, A534S, A554S  
>KNH1209| codons 1-560
PISPIETVPVELKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HKSFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRSKNPEIII
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYAGIRIKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKNPVHGVYYDPSKDLVAEIQKQGQEQWTYQIYQEPFKNLKTGKYARKRST
HTNDVKQLAEVVQKVAMESIVIWGKTPKFKLPIQKETWETWWMDHWQATWIPEWEFVNTP
PLVKLWYQLEKDPIMGAETFYVDGAANRQTKLGKAGYVTDRGRQKVVSLPETTNQKTELY
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESEIVNQIIEQLIEKDRVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Dowling, WE Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS, 2002