Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KNH1135 | KNH1135 | Kenya | 1999 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, A21T, V31I, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, L234I | S283G |
| >KNH1135| codons 1-288 FLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, R57K, D60E, L63S, H69K, L89M |
| >KNH1135| codons 1-99 PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEDINLSGKWKPRMIGGIGGFIKVKQYE QISIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39A, S48E, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, V245I, D250E, A272P, K275Q, K277R, E291D, V292I, I293V, P294T, E312D, D324E, G335E, M357K, G359S, A360T, K366R, T369A, A371V, I375V, A376V, T377M, K385R, K395R, E399D, A400T, T403M, E404D, E432D, V435E, D471E, Q480H, H483Y, L491S, E514D, S519N, Q524R, K527G, E529D, A534S, A554S, V559I |
| >KNH1135| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPEKESWTVNDIQKLVGKLNWASQIYPGIQVRQLCKLLRGTKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKELIAEIQKQGQEQWTYQIYQEPFKNLKTGKYARKRST HTNDVRQLAEVVQKVVMESIVIWGRTPKFKLPIQRETWDTWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIEGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSDSELVNQIIERLIGKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKIL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |