Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KNH1088 | KNH1088 | Kenya | 1999 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, R20K, V31I, M50I, I60M, I72V, T112V, I113V, T125A, V126F, I135V, K136Q, D167E, V201I, N222K, L234I, A265V | S283G |
| >KNH1088| codons 1-288 FLDGIDKAQEEHERYHSNWKAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGM WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSTAFKAACWWAGVQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQKFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89M |
| >KNH1088| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6S, V35T, V60I, K122E, D123G, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245K, E248D, D250E, A272P, K275R, T286V, I293V, P294T, E312N, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377L, A400T, T403M, E404D, E432D, R461K, D471E, K476Q, Q480H, L491S, K512R, S519N, Q520L, Q524K, K527G, E529D, A534S, A554S |
| >KNH1088| codons 1-560 PISPISTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPDKESWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGVKALTEVVTLTEEAE LELAENREILKNPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVKQLAEVVQKVVLESIVIWGKTPKFKLPIQKETWETWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDKGRQKVVSLTETTNQQTELH AIHLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNLIIEKLIGKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |