Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt254 | J112MA | South Africa | 1999 | HIV1 | C | PBMC | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E10D, V31I, S39G, M50I, I72V, I84L, L101I, T112V, T124A, T125A, K136Q, D167E, A169T, V201I, K211R, T218I, L234I, R269K, D278A | S283G |
| >J112MA| codons 1-288 FLDGIDKAQDEHEKYHSNWRAMASDFNLPPIVAKEIVAGCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYLEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQTEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, I15V, L19I, E35D, M36I, R41K, H69K, L89M, I93L |
| >J112MA| codons 1-99 PQITLWQRPLVTIRVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V8A, K22R, V35T, T39E, S48T, V60I, K122E, D123S, A158S, K173A, D177E, T200A, Q207E, R211K, V245K, A272P, E291D, V292I, I293V, I329L, G335D, R356K, M357R, G359T, T377L, K390R, A400T, E404D, I434M, V435A, A437V, L452K, K454R, S468T, D471E, H483Q, L491P, K512R, S519N, Q524E, E529K, K530R, A534S, A554S |
| >J112MA| codons 1-560 PISPIETAPVKLKPGMDGPKVRQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPMAGVETFYVDGAANRETKKGRAGYVTDRGRQKVVTLTETTNQKTELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDRSESELVNQIIEELIKKKRVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |