<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt241 1178MB South Africa 1999 HIV1 C PBMC MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, M50I, I72V, P90S, F100Y, L101I, T112V, T124S, T125A, K127R, K136Q, K160R, G193D, V201I, L234I, A265V, R269K, D278A S283G, D286N
>1178MB| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVISAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSSAVRAACWWAGIQQEFGIPYNPQSQGVVESMNKELKRIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGDYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQNED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    K14S, I15V, L19V, M36I, N37D, H69K, L89M, I93L  
>1178MB| codons 1-99
PQITLWQRPLVTISVGGQVKEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  D67G     K20R, V35K, E36A, T39E, S48T, K122E, D123G, I142T, A158S, K166R, K173A, Q174K, D177E, G196M, T200A, Q207E, V245Q, A272P, K277R, L279M, T286A, E291D, I293V, Q334S, G335D, R356K, M357K, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E413D, V435A, V466T, L469I, D471E, H483Q, L491S, S519N, K530R, A534S, A554K  
>1178MB| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKAICEEMEKEGKITKIGPENPYNTPV
FAIKKKGSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPSIFQSSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIMQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQMCKLLRGAKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGSDQWTYQIYQEPFKNLKTGKYAKKRTA
HTNDVRQLTEAVQKIAMESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPDWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKTVSITETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006