Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt241 | 1178MB | South Africa | 1999 | HIV1 | C | PBMC | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, M50I, I72V, P90S, F100Y, L101I, T112V, T124S, T125A, K127R, K136Q, K160R, G193D, V201I, L234I, A265V, R269K, D278A | S283G, D286N |
| >1178MB| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVISAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSSAVRAACWWAGIQQEFGIPYNPQSQGVVESMNKELKRIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGDYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQNED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14S, I15V, L19V, M36I, N37D, H69K, L89M, I93L |
| >1178MB| codons 1-99 PQITLWQRPLVTISVGGQVKEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67G | K20R, V35K, E36A, T39E, S48T, K122E, D123G, I142T, A158S, K166R, K173A, Q174K, D177E, G196M, T200A, Q207E, V245Q, A272P, K277R, L279M, T286A, E291D, I293V, Q334S, G335D, R356K, M357K, G359T, K366R, T377M, T386I, K390R, A400T, E404D, E413D, V435A, V466T, L469I, D471E, H483Q, L491S, S519N, K530R, A534S, A554K |
| >1178MB| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALKAICEEMEKEGKITKIGPENPYNTPV FAIKKKGSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPSIFQSSMTRILEPFRAKNPEIVI YQYMDDLYVGSDLEIMQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQMCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGSDQWTYQIYQEPFKNLKTGKYAKKRTA HTNDVRQLTEAVQKIAMESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPDWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKTVSITETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |