Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt236 | 1165MB | South Africa | 1999 | HIV1 | C | PBMC | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, I72V, I84M, Q95R, L101V, T112A, T124A, T125A, F181L, K188R, V201I, K211T, L234I, A265V, D278A | S283G |
| >1165MB| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGRETAYFVLKLAGRWPVKAIHTDNGSN FTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV LIHNFKRRGGIGGYSAGERIIDIIATDIQTTELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, R41K, L63P, H69K, T74S, L89M, I93L |
| >1165MB| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, K122E, D123G, T165I, K173T, Q174K, D177E, G196E, T200A, Q207A, V245Q, D250E, A272S, K277R, T286A, E291D, V292I, I293V, K311R, Q334D, G335D, R356K, M357R, G359S, T377M, K390R, A400I, E404D, V435A, L452I, V466I, T470S, D471E, Q480H, H483Q, L491S, S519N, K527N, V531I, A534S, A554S | M16I |
| >1165MB| codons 1-560 PISPIETVPVKLKPGIDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRTKNPEIVI YQYMDDLYVGSDLEIEQHRAKIEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRSA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKIGKAGYVTDRGRQKIVSLSETTNQKTELH AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKEKIYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |