Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt61 | 03PS116MB1 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E10D, D25E, V31I, M50I, I72V, L74I, I84M, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D253E, S255N, D270G, D278A | S283G |
| >03PS116MB1| codons 1-288 FLDGIDKAQDEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVIIVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQENNDIKVVPRRKAKIIRGYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, K14R, I15V, L19V, E35D, N37S, R41K, L63P, H69K, L89M, I93L |
| >03PS116MB1| codons 1-99 PQITLWQRPLVSIRVGGQVKEALLDTGADDTVLEDMSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207K, V245K, K277R, T286A, E291D, V292I, I293V, D324E, Q334E, G335D, R356K, M357R, G359A, T377M, K390R, A400T, E404D, I434M, V435A, A437V, K451R, L452M, S468T, D471E, H483Q, S519N, Q524E, K530R, A534S, A554S, K558R |
| >03PS116MB1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRKHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEDQWTYQIYQEPFKNLKTGKYAKRRAA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPMAGVETFYVDGAANRETRMGKAGYVTDRGRQKVVTLTETTNQKTELQ AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRRVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |