Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt34 | 03PS059MB2 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, M50T, G70E, L74I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, L234I, R269K, D278A | S283G |
| >03PS059MB2| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEATHGQVDCSPGI WQLDCTHLEEKIIIVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19T, K20R, E35D, R41K, Q61E, L63P, H69K, V77I, L89M, I93L |
| >03PS059MB2| codons 1-99 PQITLWQRPLVSIKVGGQTREALLDTGADDTVLEDMNLPGKWKPKMIGGIGGFIKVRQYD EIPIEICGKKAIGTVLIGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39D, S48T, K122E, K173A, Q174E, D177E, T200A, Q207E, R211K, V245Q, S251N, A272P, K275R, T286A, E291D, V292I, I293V, E312Q, V317A, D324E, Q334H, G335D, R356K, G359T, T377M, K390R, E404D, V435A, R461K, V466T, S468T, D471E, H483Q, L491S, S519N, K527Q, K530R, A534S, A554S | G45R |
| >03PS059MB2| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKERKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAENPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDNWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKQPVHGAYYDPSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDKGRQKTVTLTETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |