<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt190 04SK152MB1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S17N, D25E, V31I, S39N, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, R269K, D278A S283G
>04SK152MB1| codons 1-288
FLDGIDKAQEDHEKYHNNWRAMASEFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, E35D, N37H, R41K, Q61E, L63P, I64L, H69K, L89M, I93L  
>04SK152MB1| codons 1-99
PQITLWQRPLVSIKVGGQLKEALLDTGADDTVLEDMHLPGKWKPKMIGGIGGFIKVRQYD
EIPLEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32R, V35T, E36A, T39E, S48T, E53D, T165X, K173A, Q174K, D177E, T200A, I202V, Q207A, R211K, V241I, V245Q, A272P, T286A, E291D, V292I, E328D, Q334H, G335D, R356K, M357V, R358K, G359A, K366R, T377M, K390R, A400T, E404D, V435A, A437V, L452I, K454R, R461K, V466I, S468T, D471E, H483Q, L491P, V493I, L517I, S519N, K530R, A534S, A554Q L234P
>04SK152MB1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALTAICEEMEKEGKITKIGPDNPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMXKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKVEELRAHLLKWGFTTPDKKHQKEPPFLWMGYEPHPDKWT
IQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIADIQKQGHDQWTYQIYQEPFKNLKTGKYAKVKAA
HTNDVRQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGVETFYVDGAANRETKIGRAGYVTDKGRQKIVTLTETTNQKTELQ
AIQLALQDSGPEINIVTDSQYALGIIQAQPDKSESEIVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSQGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006