<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt193 04SK162B1 South Africa 2004 HIV1 A Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, E13D, A21T, V31I, G106A, K111R, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, P233S, L234V, K240R, D256E  
>04SK162B1| codons 1-288
FLDGIDKAQEDHDKYHSNWRTMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAARWPVRVIHTDNGSN
FTSAAVKAACWWANVQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDSVWKGPAR
LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, E35D, M36I, R41K, H69K, L89M  
>04SK162B1| codons 1-99
PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6K, V35T, K122E, I135T, I142V, K173S, I202V, R211S, F214L, V245Q, E248D, A272S, K277R, T286A, E291D, I293V, E312N, S322A, G335D, R356K, M357K, G359S, A371V, I375V, A376V, A400T, T403M, Y405C, E432D, V435L, S468P, D471E, Q480H, H483Y, L491P, K512R, S515A, L517I, S519N, Q524K, K527E, K530R, A534S, A554S, K558R K13R
>04SK162B1| codons 1-560
PISPIKTVPVKLRPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPDIVI
YQYMDDLYVGSDLEIGQHRTKVEELRQHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGAKALTDVVPLTEEAE
LELAENREILKNPVHGVYYDPAKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTEVVQKVVTESIVIWGKTPKFKLPIQKETWETWWMECWQATWIPEWEFVNTP
PLVKLWYQLEKDPILGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTETTNQKTELH
AIYLALQDSGPEVNIVTDSQYALGIIQAQPDRSEAEIVNQIIEKLIEKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRRVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006