Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt216 | 04SK193B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, K34R, M50I, L74I, A91E, F100Y, L101I, T112V, S119R, T125A, K136Q, V201I, T218I, L234I, A265V, D278A | S283G |
| >04SK193B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAREIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIIIVAVHVASGYIEAEVIPEETGQETAYYILKLAGRWPVKVIHTDNGRN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36I, R41K, Y59C, D60E, L63P, H69K, L89M, I93L |
| >04SK193B1| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQCE QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, S68G, K122E, D123S, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K275R, Q278N, T286A, V292I, R356K, M357T, G359T, A360T, K366R, T377W, K390R, E399D, A400L, E404D, V435A, G436E, N447H, L452I, V466I, D471E, T477A, Q480H, I482V, H483Q, L491S, S519N, K527N, E529D, K530R, A534S, A554S |
| >04SK193B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLLRGAKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRTT HTNDVRQLTEAVQKIAWESIVIWGKTPKFRLPIQKETWDLWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEAETFYVDGAAHRETKIGKAGYVTDRGRQKIVSLTETTNQKAELH AVQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKDRVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |