Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt196 | 04SK165B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, L45Q, M50I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, L234I, N254Q, D278A | S283G |
| >04SK165B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEIVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDQSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, N37S, R41K, L63P, H69K, I93L |
| >04SK165B1| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, K122E, D123N, K173A, T200A, Q207D, R211K, V245Q, K277R, E291D, V292I, I293V, S322A, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, E432D, I434M, A437V, L452A, V467I, D471E, H483L, L491S, S519N, K527N, K530R, A534S, A554S |
| >04SK165B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKDPMVGVETFYVDGAANRETKAGKAGYVTDRGRQKVISLTETTNQKTELQ AILLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |