Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt59 | 03PS112MB2 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, I72V, L101I, T112V, T124A, K136Q, V201I, I220V, Y227F, L234I, S255N, A265V, D278A | V281M, S283G |
| >03PS112MB2| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN FTSATVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKVQNFRVYFRDSRDPIWKGPAK LLWKGEGAVVIQDNNDIKVVPRRKVKIIRDYGKQMAGADCMAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, N37S, R41K, H69K, I93L |
| >03PS112MB2| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K32N, V35K, E36A, T39E, S48T, K122E, D123S, I142V, S162A, K173T, Q174K, D177E, G196E, T200A, Q207D, R211K, V245Q, E248I, A272S, L283I, E291D, V292I, I293V, P313T, V317A, K331E, Q334G, G335D, R356K, G359T, K390R, A400T, E404D, V435I, A437V, E449D, L452I, K465R, V467I, D471E, H483Q, L491S, S519N, K527N, K530R, A534S, A554S |
| >03PS112MB2| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALKAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI YQYMDDLYVGSDLEIEQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPIKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLIRGTKALTDIVPLTEEAE LELAENREILKETVHGAYYDPSKDLIAEIQEQGGDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGVETFYVDGAANRDTKIGKAGYVTDRGRQRVISLTETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |