<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt199 04SK169B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, I72V, I84M, L101I, T112V, T124A, T125A, K136Q, V201I, I217V, T218L, L234I, R269K, D278A S283G
>04SK169B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQVLKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T4A, T12S, I15V, L19I, K20R, E35D, M36I, R41K, H69K, L89M, I93L, L97I  
>04SK169B1| codons 1-99
PQIALWQRPLVSIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTINF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, S48T, V60I, W88C, K122E, K166R, K173A, T200V, E204K, Q207A, R211K, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V, T296A, K311R, D324E, Q334D, G335D, R356K, M357R, G359T, T377I, K390R, A400T, E404D, I434M, V435A, A437V, L452I, R461K, S468T, D471E, H483Q, L491S, S519N, Q524E, A534S, I542T, A554R  
>04SK169B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPDIVI
YQYMDDLYVGSDLEIGQHRVKIEKLRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLAEEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAIESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRETKIGKAGYVTDKGRQKVVTLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKEKVYLSWVPAHK
GTGGNEQVDKLVSRGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006