<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt31 03PS055MB1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, D25E, V31I, M50I, I72V, I84M, F100Y, L101I, T112V, S119P, T125A, K136Q, M154V, V201I, T218I, L234I, A265V, D278A S283G
>03PS055MB1| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESVNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, M36I, N37S, R41K, L63T, C67Y, H69K, L89M, I93L  
>03PS055MB1| codons 1-99
PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD
QITIEIYGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  T215A     V35T, E36V, T39E, S48T, K122E, D123G, T165I, K166R, K173T, D177E, T200A, Q207E, R211K, V245K, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, R358T, G359T, E370G, T377M, T386I, K390R, A400T, E404D, I434M, V435A, A437V, L452M, V467I, S468T, L469I, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
>03PS055MB1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTVICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIRILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFATPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRTTA
HTNDVKQLTGAVQKIAMESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRETKMGKAGYVTDRGRQKVITITETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006