Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt226 | 05SK243B1 | South Africa | 2005 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, M50I, I72V, T112V, K136Q, E157T, K160E, V201I, T206S, I208M, L234I, D278A | S283G |
| >05SK243B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVIHTDNGSN FTSTTVKAACWWAGIQQEFGIPYNPQSQGVVESMNKTLKEIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDMQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I13V, I15V, L19I, K20R, M36I, R41K, H69K, L89M, I93L |
| >05SK243B1| codons 1-99 PQITLWQRPLVSVKVGGQIREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, K122E, D123S, E138A, K173A, Q174K, T200A, Q207D, R211K, V245Q, K275Q, K281R, T286A, E291D, V292I, I293V, E297K, V317G, Q334S, G335D, R356K, G359T, K366R, T377S, T386I, K390R, A400I, E404D, V435A, A437V, L452I, V466I, S468H, T470S, D471E, Q480K, L491S, S519N, A534S, A554S |
| >05SK243B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCRLLRGAKALTDIVPLTKEAE LELAENREILKEPVHGGYYDPSKDLIAEIQKQGSDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVRQLTEAVQKIASESIVIWGKIPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKIGKAGYVTDRGRQKIVHLSETTNQKTELK AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |