<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt60 03PS113MB2 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E10D, V31I, M50I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211R, T218I, L234I, A265V, R269K, D278A S283G
>03PS113MB2| codons 1-288
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I13V, I15V, L19I, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89M, I93L  
>03PS113MB2| codons 1-99
PQITLWQRPLVSVKVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, K102R, K122E, D123N, K166R, K173A, D177E, T200A, Q207K, V245Q, E248T, A272P, K277R, T286A, E291D, V292I, I293V, P294T, Q334N, R356K, G359T, A371V, T377M, K390R, A400T, E404D, E432D, N447S, L452M, R461K, V466I, S468H, D471E, H483Q, L491P, Q507H, K527G, K530R, A534S, V548I, A554S K11M
>03PS113MB2| codons 1-560
PISPIETVPVMLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRKHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPTKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAASRETKMGKAGYVTDKGRQKIVHLTETTNQKTELQ
AIQLALQDSGPEVNIVTDSQYALGIIHAQPDKSESELVSQIIEQLIGKERVYLSWVPAHK
GIGGNEQIDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006