Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt227 | 05SK244B1 | South Africa | 2005 | HIV1 | CRF49_cpx | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| T97A | D25E, V31I, M50I, I72V, L101I, T112V, S119T, T124A, K136Q, V201I, T218I, L234I, D278A | S283G |
| >05SK244B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQEAAYFILKLAGRWPVKVIHTDNGTN FTSATVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, L19V, M36I, R41K, L63Q, H69K, T74S, L89M, I93L |
| >05SK244B1| codons 1-99 PQITLWQRPLVSIKIGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIQIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V8I, V35T, E36A, T39E, S48T, V60I, K66E, K122E, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, A272P, K277T, T286A, E291D, V292I, I293V, Q334C, G335D, R356K, M357R, G359T, T377M, K390R, A400I, E404D, E432D, V435A, L452I, R461K, V466I, S468T, T470S, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S | G99W |
| >05SK244B1| codons 1-560 PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKEDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAWLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVTQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGCDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIAGAETFYVDGAANRETKIGKAGYVTDKGRQKIVTLSETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |