Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt229 | 05SK246B1 | South Africa | 2005 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A | S283G |
| >05SK246B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, E35D, M36I, R41K, L63P, H69K, T74S, L89M, I93L | L90S |
| >05SK246B1| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGSVLVGPTPVNIIGRNMSTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| P4S, K11R, V35T, E36A, T39E, S48T, V60I, K64R, K122E, I142K, K166R, K173A, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K275Q, E291D, V292I, I293V, Q334Y, R356K, G359T, T377L, K390R, A400I, E404D, V435A, G436E, A437V, L452I, V466I, D471E, T477A, H483Q, L491S, V518A, S519N, Q520K, K527E, K530R, V531I, A534S, A554N |
| >05SK246B1| codons 1-560 PISSIETVPVRLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIRKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGKRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKVEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIQVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEVETFYVDGAANRETKIGKAGYVTDRGRQKIVSLTETTNQKAELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELANKIIEQLIEKERIYLSWVPAHK GIGGNEQVDKLVSNGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |