<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt63 03PS119MB1 South Africa 2003 HIV1 A Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, S17T, V31I, I72V, G106A, T112V, T124A, T125A, G134N, I135V, K136Q, V201I, L234I, K240R S283G
>03PS119MB1| codons 1-288
FLDGIDKAQEEHERYHTNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAARWPVKVIHTDNGSN
FTSAAVKAACWWANVQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAR
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, E35D, M36I, R41K, L63Q, H69K, L89M  
>03PS119MB1| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIQIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K11T, K20R, V35T, V60I, K122E, D123N, I135T, E138A, I142V, K173A, Q174R, D177G, G196E, I202V, Q207A, R211S, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, Q334D, R356K, G359T, K366R, T369V, Q373H, T377L, K390R, A400I, E404D, E432D, V435L, L452M, V466I, V467I, T470S, D471E, Q480H, H483K, L491P, S519N, K530R, A534S, A554S  
>03PS119MB1| codons 1-560
PISPIETVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNATPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRARNPGIVI
YQYMDDLYVGSDLEIEQHRTKVEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLVEAVHKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPILGAETFYVDGAANRETKMGKAGYVTDRGRQKIISLSETTNQKTELH
AIKLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006