Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt125 | 03SK113B1 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| Y143H | D25E, V31I, M50I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A | S283G |
| >03SK113B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPHNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | I15V, G16E, L19I, K20M, M36I, R41K, D60E, L63H, G68E, H69K, L89I, I93L, L97I |
| >03SK113B1| codons 1-99 PQITLWQRPLVTIKVEGQIMEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE QIHIEICEKKAIGTVLVGPTPANIIGRNILTQLGCTINF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| P4S, E6D, V35T, E36A, T39E, E40D, K122E, D123S, S134G, A158S, K173T, T200A, Q207E, R211K, V245L, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334R, G335D, R356K, M357L, G359T, T377L, K390R, A400T, E404D, V435A, R461K, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S, K558R |
| >03SK113B1| codons 1-560 PISSIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKNLKTGKYAKLRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDKGRQKVVSLTETTNQKAELQ AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK GIGGNEQVDKLVSSGIRRVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |