<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt125 03SK113B1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
Y143H   D25E, V31I, M50I, I84M, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A S283G
>03SK113B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPHNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82A   I15V, G16E, L19I, K20M, M36I, R41K, D60E, L63H, G68E, H69K, L89I, I93L, L97I  
>03SK113B1| codons 1-99
PQITLWQRPLVTIKVEGQIMEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE
QIHIEICEKKAIGTVLVGPTPANIIGRNILTQLGCTINF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        P4S, E6D, V35T, E36A, T39E, E40D, K122E, D123S, S134G, A158S, K173T, T200A, Q207E, R211K, V245L, A272P, K277R, T286A, E291D, V292I, I293V, V317A, Q334R, G335D, R356K, M357L, G359T, T377L, K390R, A400T, E404D, V435A, R461K, D471E, T477A, H483Q, S519N, K527N, K530R, V531I, A534S, A554S, K558R  
>03SK113B1| codons 1-560
PISSIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKNLKTGKYAKLRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDKGRQKVVSLTETTNQKAELQ
AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSSGIRRVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006