Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt141 | 04PS165MB1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, A21S, S24A, I72V, I84M, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, V201I, T206S, T218I, L234I, A265V, R269K, D278A | S283G |
| >04PS165MB1| codons 1-288 FLDGIDKAQEEHEKYHNNWRSMAADFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36I, R41K, L63R, H69K, K70E, L89M, I93L |
| >04PS165MB1| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIRIEICGKEAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, K173A, Q174K, D177E, V189I, T200A, Q207E, R211K, V245Q, A272P, T286A, A288T, E291D, V292I, I293V, Q334D, G335D, R356K, M357K, G359T, T377L, T386I, K390R, A400I, E404D, V435A, N447S, L452M, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554N |
| >04PS165MB1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYIGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKKRTA HTNDVKQLTEAVQKIALESIVIWGKIPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAASRETKMGKAGYVTDRGRQKIVSLTETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSNGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |