Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt54 | 03PS103MB2 | South Africa | 2003 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, D25E, V31I, I72V, I84M, V88I, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, D167E, V201I, T206S, T218I, L234I, R269K, D278A | S283G |
| >03PS103MB2| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYMEAEIIPAETGQETAYYILKLAGRWPVKVIHTDNGPN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, K14R, I15V, L19I, K20R, M36I, R41K, D60N, I62V, L63V, H69K, T74S, L89M, I93L |
| >03PS103MB2| codons 1-99 PQITLWQRPLVSIRVGGQIREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYN QVVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11Q, V35T, E36A, T39E, S48T, V60I, K122E, D123S, K173A, Q174K, D177E, D192G, I195V, T200A, Q207E, V245K, A272P, R284K, E291D, V292I, I293V, H315Y, Q334D, G335D, R356K, M357R, G359T, K366R, T377Q, K390R, Q394H, E404D, I434M, V435A, A437V, L452I, S468T, T470A, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S |
| >03PS103MB2| codons 1-560 PISPIETVPVQLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI YQYMDDLYVGSGLEVGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTDIVPLTEEAE LELAENREILKEPVYGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVRQLTEAVQKIAQESIVIWGKTPKFRLPIHKETWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPMAGVETFYVDGAANRETKIGKAGYVTDRGRQKVVTLAETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |