<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt39 03PS073MB1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, S17N, D25E, V31I, S39N, M50T, F100Y, L101I, T112V, T125A, K136Q, G163E, V201I, I203M, T218I, L234I, A265V, D278A S283G
>03PS073MB1| codons 1-288
FLDGIEKAQEEHEKYHNNWRAMASEFNLPPIVAKEIVANCDKCQLKGEATHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIEQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L   T12S, I15V, L19I, M36I, N37S, R41K, R57K, D60E, H69K, I85V, L89M, I93L  
>03PS073MB1| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEISLPGKWKPKLIGGIGGFIKVKQYE
QILIEICGKKAIGTVLVGPTPVNIVGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        P4S, V35T, E36A, T39E, S48T, V118I, K122E, D123S, T165I, K166R, K173T, Q174K, T200A, Q207E, F214L, V245M, D250N, A272P, K275R, T286A, E291D, V292I, I293V, Q334H, R356K, M357V, G359T, V365I, T386I, K390R, E396G, A400T, E404D, V435A, L452I, R461K, V466I, D471E, T477A, E478G, H483Q, L491S, S513G, S519N, K527N, K530R, V531I, A534S, A554R, K558R  
>03PS073MB1| codons 1-560
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIRILEPFRTKNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKNSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYAKVRTA
HTNDIKQLTEAVQKIATESIVIWGKIPKFRLPIQKGTWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKIGKAGYVTDKGRQKIVSLTETTNQKAGLQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKGESELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSRGIRRVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006