Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt154 | 04PS195B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, K188R, V201I, T218I, L234I, A265V, D278A | S283G |
| >04PS195B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRRGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q7R, T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93L |
| >04PS195B1| codons 1-99 PQITLWRRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V8I, K20R, V35T, E36A, T39E, S48T, K102R, K122E, D123G, F124L, S162C, K166R, K173T, D177E, T200A, E204K, Q207E, R211K, V245Q, D250E, A272P, K277T, T286A, E291D, V292I, I293V, E298A, I329L, Q334H, G335D, P345S, R356K, M357R, G359T, T369A, T377M, K390R, A400T, E404D, E413D, V435A, A437V, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, Q509H, S519N, K530R, A534S, A554S | T253A |
| >04PS195B1| codons 1-560 PISPIETIPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEGLRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRTQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEKLREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWAVNDIQKLVGKLNWASQIYPGIKVTQLCKLLRGAKALTDIVPLTEAAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGHDQWTYQIYQESFKNLKTGKYAKRRTA HTNDVKQLAEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPDWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKIGKAGYVTDRGRQKIVTLNETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAHPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |