<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt154 04PS195B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, K188R, V201I, T218I, L234I, A265V, D278A S283G
>04PS195B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRRGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    Q7R, T12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93L  
>04PS195B1| codons 1-99
PQITLWRRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V8I, K20R, V35T, E36A, T39E, S48T, K102R, K122E, D123G, F124L, S162C, K166R, K173T, D177E, T200A, E204K, Q207E, R211K, V245Q, D250E, A272P, K277T, T286A, E291D, V292I, I293V, E298A, I329L, Q334H, G335D, P345S, R356K, M357R, G359T, T369A, T377M, K390R, A400T, E404D, E413D, V435A, A437V, L452I, V466I, S468T, T470N, D471E, H483Q, L491S, Q509H, S519N, K530R, A534S, A554S T253A
>04PS195B1| codons 1-560
PISPIETIPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL
DEGLRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEKLREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWAVNDIQKLVGKLNWASQIYPGIKVTQLCKLLRGAKALTDIVPLTEAAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGHDQWTYQIYQESFKNLKTGKYAKRRTA
HTNDVKQLAEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPDWEFVNTP
PLVKLWYQLEKEPIAGVETFYVDGAANRETKIGKAGYVTDRGRQKIVTLNETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAHPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006