Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt187 | 04SK147B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E10V, S17N, D25E, V31I, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, T218I, L234I, D256E, A265V, D278A | S283G |
| >04SK147B1| codons 1-288 FLDGIDKAQVEHEKYHNNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, K20R, E35D, M36I, R41K, L63I, H69K, L89M, I93L |
| >04SK147B1| codons 1-99 PQITLWQRPLVSIKVGGQVREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIIIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39D, S48T, V60I, K122E, D123G, S162N, K166R, K173A, Q174K, D177E, T200A, Q207A, V245Q, A272P, K277S, T286A, E291D, V292I, I293V, R307G, D324E, Q334R, G335D, R356K, M357R, G359T, T377L, T386I, K390R, A400T, E404D, V435T, V466I, S468H, D471E, H483Q, L491S, E492A, S519N, A534S, A554K | N81S |
| >04SK147B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELSKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVSQLCKLLRGAKALTDIVPLTEEAE LELAENGEILKEPVHGVYYDPSKELIAEIQKQGRDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIALESIVIWGKIPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPITGAETFYVDGAANRETKLGKAGYVTDRGRQKIVHLTETTNQKTELQ AIQLALQDSGSAVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |