<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt158 04PS201B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, E13A, D25E, V31I, L45Q, M50I, I72V, F100Y, T112V, T124S, T125A, I135V, K136Q, V201I, K215N, L234I, A265V, D278A S283G
>04PS201B1| codons 1-288
FLDGIDKAQEDHAKYHSNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYLLKLAGRWPVKVIHTDNGSN
FTSSAVKAACWWAGVQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQNQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L19T, K20R, E35D, M36I, R41K, L63T, H69K, L89M, I93L  
>04PS201B1| codons 1-99
PQITLWQRPLVTIKIGGQTREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, K166R, K173A, Q174K, D177E, T200A, Q207A, R211K, V245Q, D250E, A272S, K277R, T286A, K287R, E291D, V292I, I293V, P313T, Q334E, G335D, P345S, R356K, M357R, G359T, I375X, T377M, S379C, K390R, A400I, E404D, L452K, V458I, T470S, D471E, H483Q, L491S, S519N, A534S, A554N  
>04PS201B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGARALTDIVPLTEEAE
LELAENREILKETVHGVYYDPSKDLIAEIQKQGEDQWTYQIYQESFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKXAMECIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKKGKAGYITDRGRQKVVSLSETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006