Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt157 | 04PS199B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, I72V, F100Y, L101I, T112V, T124N, T125A, K136Q, V201I, K215N, L234I, A265V, R269K, D278A | D288N |
| >04PS199B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSNAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQNQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVASRQDEN |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19T, M36I, R41K, H69K, L89M, I93L |
| >04PS199B1| codons 1-99 PQITLWQRPLVTIKIGGQTKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K32R, V35T, T39K, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, T286A, E291D, V292I, I293V, P294L, Q334Y, G335D, R356K, M357R, G359T, K390R, A400L, E404D, I434V, V435A, N447T, L452I, T470S, D471E, T477A, H483Q, L491S, V493A, S519N, K530R, A554K | E89G, Y232C |
| >04PS199B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALTEICKEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWGVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGCELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVLLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWELWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPVAGAETFYVDGAATRETKIGKAGYVTDRGRQKVVSLSETTNQKAELQ AIQLALQDSGSEANIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSKGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |