Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt180 | 04SK137B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| Y143H | K14R, A21S, D25E, V31I, K34R, E96G, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211R, T218I, L234I, D279G | S283G |
| >04SK137B1| codons 1-288 FLDGIDKAQEEHERYHSNWRSMASEFNLPPIVAREIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQGTAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPHNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDGCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I3V, I15V, L19V, M36I, R41K, Q61E, L63P, H69K, L89M, I93L |
| >04SK137B1| codons 1-99 PQVTLWQRPLVTIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD EIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39D, S48T, V60I, R83K, D121Y, K122E, T165I, K173A, Q174K, D177E, G196E, T200A, Q207T, R211K, V245Q, D250E, V261X, A272S, K277R, T286A, E291D, V292I, I293V, P313T, V317A, S322A, Q334E, R356K, G359S, T377L, K390R, A400T, E404D, V435A, N447S, E449D, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554N | N265S |
| >04SK137B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPEIVI YQYMDDLYVGSDLEIEQHRAKIEELRTHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLXGKLSWASQIYSGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKETVHGAYYDPAKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAASRDTKLGKAGYVTDRGRQKIVSLTETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSNGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |