<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt180 04SK137B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
Y143H   K14R, A21S, D25E, V31I, K34R, E96G, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K211R, T218I, L234I, D279G S283G
>04SK137B1| codons 1-288
FLDGIDKAQEEHERYHSNWRSMASEFNLPPIVAREIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQGTAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPHNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDGCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I3V, I15V, L19V, M36I, R41K, Q61E, L63P, H69K, L89M, I93L  
>04SK137B1| codons 1-99
PQVTLWQRPLVTIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
EIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, S48T, V60I, R83K, D121Y, K122E, T165I, K173A, Q174K, D177E, G196E, T200A, Q207T, R211K, V245Q, D250E, V261X, A272S, K277R, T286A, E291D, V292I, I293V, P313T, V317A, S322A, Q334E, R356K, G359S, T377L, K390R, A400T, E404D, V435A, N447S, E449D, V466I, D471E, H483Q, L491S, S519N, K530R, A534S, A554N N265S
>04SK137B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIEQHRAKIEELRTHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLXGKLSWASQIYSGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKETVHGAYYDPAKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAASRDTKLGKAGYVTDRGRQKIVSLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006