<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt200 04SK170B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, M50I, I72V, A91E, F100Y, L101I, T112V, S119R, T124A, T125A, K136Q, K188R, E198G, V201I, T218I, L234I, A265V, R269K, D278A S283G
>04SK170B1| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPEETGQETAYYILKLAGRWPVKVIHTDNGRN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRRGGIGGYSAGGRIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I3V, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L  
>04SK170B1| codons 1-99
PQVTLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  D67G   A98G V8I, V35T, E36A, T39E, S48T, D86E, K122E, D123N, K173A, D177E, I178M, T200E, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, Q334Y, G335D, R356K, M357R, G359T, K374R, T377M, T386I, K390R, T397A, A400T, E404D, E432D, V435A, A437V, L452M, V466I, S468T, D471E, T477A, H483Q, L484I, L491S, Q507H, K527N, K530R, A534S, A554S  
>04SK170B1| codons 1-560
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKGSTKWRKLVDFRELNKRTQEFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEMVI
YQYMDDLYVGSDLEIGQHREKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQRIAMESIVIWGKIPKFRLPIQKEAWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIAGVETFYVDGAANRETKMGKAGYVTDRGRQKIVTLTETTNQKAELQ
AIQIALQDSGSEVNIVTDSQYALGIIHAQPDKSESELVSQIIEQLINKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006