<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt207 04SK178B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24N, D25E, V31I, L45Q, M50I, I72V, I84V, F100Y, L101I, T112V, T124A, T125A, K136Q, G193E, V201I, T218I, L234I, D278A S283G
>04SK178B1| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMANEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYVEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGEYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, E35D, M36I, R41K, H69K, T74S, L89M, I93L  
>04SK178B1| codons 1-99
PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, V35T, T39E, S48T, V60I, K122E, D123G, T165I, K173A, Q174K, D177E, T200A, I202V, Q207E, R211G, F214L, K238R, V245Q, A272P, K275Q, V276T, K277R, Q278H, T286V, E291D, I293V, P294T, Q334E, T338S, R356K, G359T, K366R, T377L, K390R, A400I, E404D, V435A, G436E, L452M, V458I, R461K, V467I, D471E, H483Q, L491P, S519N, K530R, A534S, A554S  
>04SK178B1| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKVEELREHLLGWGLTTPDKKHQKEPPFLWMGYELHPDRWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIQTRHLCKLLRGVKALTDVVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWSYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLTEAVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAEAETFYVDGAANRETKMGKAGYITDKGRQKVISLTETTNQKTELQ
AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006