Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt207 | 04SK178B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, S24N, D25E, V31I, L45Q, M50I, I72V, I84V, F100Y, L101I, T112V, T124A, T125A, K136Q, G193E, V201I, T218I, L234I, D278A | S283G |
| >04SK178B1| codons 1-288 FLDGIDKAQEDHEKYHSNWRAMANEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYVEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGEYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, E35D, M36I, R41K, H69K, T74S, L89M, I93L |
| >04SK178B1| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K20R, V35T, T39E, S48T, V60I, K122E, D123G, T165I, K173A, Q174K, D177E, T200A, I202V, Q207E, R211G, F214L, K238R, V245Q, A272P, K275Q, V276T, K277R, Q278H, T286V, E291D, I293V, P294T, Q334E, T338S, R356K, G359T, K366R, T377L, K390R, A400I, E404D, V435A, G436E, L452M, V458I, R461K, V467I, D471E, H483Q, L491P, S519N, K530R, A534S, A554S |
| >04SK178B1| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKVEELREHLLGWGLTTPDKKHQKEPPFLWMGYELHPDRWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIQTRHLCKLLRGVKALTDVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWSYQIYQEPFKNLKTGKYAKMRTA HTNDVRQLTEAVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEAETFYVDGAANRETKMGKAGYITDKGRQKVISLTETTNQKTELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |