<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt217 04SK196B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, S57R, I72V, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, V201I, A205S, T218I, L234I, A265V, R269K, D278A S283G
>04SK196B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCRPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGTN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIISTDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47V   T12S, I13X, I15V, L19T, M36I, R41K, H69K, I93L  
>04SK196B1| codons 1-99
PQITLWQRPLVSXKVGGQTKEALLDTGADDTVLEEINLPGKWKPKMVGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, S162C, K173V, Q174K, D177E, T200A, Q207E, R211K, V245E, A272P, E291D, V292L, L325S, Q334D, G335D, R356K, M357R, G359T, T377M, K388R, K390R, A400T, T403S, E404D, I434M, V435A, A437V, E449D, L452M, K454R, R461K, V467I, S468T, D471E, A481T, H483Q, L491S, S519N, I521V, K530R, A534S, A554N I180T
>04SK196B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRVKNPEIVT
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDLIPLTEEAE
LELAENREILKEPVHGVYYDPSKDSIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPRFRLPIQKETWETWWSDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAGVETFYVDGAANRDTKMGRAGYVTDKGRQKVITLTETTNQKTELQ
TIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQVIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006