<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt185 04SK145B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T206S, I208L, L234I, A265V, D278A S283G
>04SK145B1| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDLQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L19I, M36I, P39S, R41K, I62V, L63P, C67S, H69K, L89M, I93L  
>04SK145B1| codons 1-99
PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEINLSGKWKPKMIGGIGGFIKVRQYD
QVPIEISGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, S162A, K173A, D177E, T200A, Q207K, R211K, F214L, V245Q, D250N, A272P, I293V, E297K, E312G, Q334D, G335D, A355X, R356K, G359T, K366R, Q367R, A376S, T377L, K390R, K395R, A400I, E404D, V435A, V466I, V467I, S468T, T470S, D471E, H483Q, L491P, I495V, L517I, S519N, K530R, A534S, A554S  
>04SK145B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRKHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKNSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKGPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYXKMRTA
HTNDVRRLTEAVQKISLESIVIWGKTPKFRLPIQRETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKIITLSETTNQKTELQ
AIQLALQDSGPEVNVVTDSQYALGIIQAQPDKSESEIVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006