Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt185 | 04SK145B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T206S, I208L, L234I, A265V, D278A | S283G |
| >04SK145B1| codons 1-288 FLDGIDKAQEEHERYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDLQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19I, M36I, P39S, R41K, I62V, L63P, C67S, H69K, L89M, I93L |
| >04SK145B1| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEINLSGKWKPKMIGGIGGFIKVRQYD QVPIEISGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135T, S162A, K173A, D177E, T200A, Q207K, R211K, F214L, V245Q, D250N, A272P, I293V, E297K, E312G, Q334D, G335D, A355X, R356K, G359T, K366R, Q367R, A376S, T377L, K390R, K395R, A400I, E404D, V435A, V466I, V467I, S468T, T470S, D471E, H483Q, L491P, I495V, L517I, S519N, K530R, A534S, A554S |
| >04SK145B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRKHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKNSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKGPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYXKMRTA HTNDVRRLTEAVQKISLESIVIWGKTPKFRLPIQRETWEIWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKIITLSETTNQKTELQ AIQLALQDSGPEVNVVTDSQYALGIIQAQPDKSESEIVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |