Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4736 | CA69141 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT+IDV | 52 |
| 3 | PI+RTI | 470 |
| 4 | EFV+FTC+RTV+TDF+TPV | 30 |
| 5 | DRV+FTC+RTV+T20+TDF | 5 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75VIM, M184V, L210W, T215Y | K219E | G190S | A98G | S3C, T39N, K43E, E44A, T69TA, V106I, D123E, I142V, V179I, T200A, I257L, T286A, V292I, I293V | W229WR |
| >CA69141| codons 1-305 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEEAGKISKIGPENPYNTPV FAIKKKNSAKWRKIMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVSSDLEIGQHRAKIEELRQHLWRWGFYTPDEKHQKEPPFLRMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIVPLTEEAE LELAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54L, I84V, L90M | V11I, L33F, G73S, L89V | L10V, I13V, K14R, I15V, K20T, M36I, R41K, R57K, D60E, L63P, G68E, K70T, A71I, I72IM, I93L |
| >CA69140| codons 1-99 PQITLWQRPVITVRVGGQLTEALLDTGADDTIFEEINLPGKWKPKLIGGIGGFLKVKQYE QIPIEICEHTIMSTVLVGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |