<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA378 CA691 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 24
2 SQV 24
3 3TC+AZT+SQV 174
4 3TC+AZT+IDV 115
5 D4T+DDI+EFV 24

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V   L10I, L38F, R41K, L63P, T74A  
>CA691| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNFPGKWKPKMIVGIGGFIKVRQYD
QIPIEICGHKAIGAVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Schapiro, JM The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients. Ann Intern Med, 1996
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005