Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1499 | CA68661 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 44 |
| 2 | DDI | 126 |
| 3 | D4T | 52 |
| 4 | 3TC+D4T | 65 |
| 5 | 3TC+D4T+IDV | 58 |
| 6 | D4T+NFV+NVP | 63 |
| 7 | 3TC+D4T+EFV+RTV+SQV | 13 |
| 8 | APV+D4T+EFV+NFV | 30 |
| 9 | APV+D4T+NFV | 28 |
| 10 | None | 56 |
| 11 | D4T+DDI+LPV | 20 |
| 12 | 3TC+ABC+DDI+LPV+TDF | 228 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N, Y181C, G190A | A98G | K20R, V35M, T39A, K43E, E44D, K64KR, K102Q, V111VIM, V118I, D123E, Q174R, D177E, V189VI, G196E, E203K, Q207E, H208Y, R211K, K223Q, A272P, T286A, E297R |
| >CA68661| codons 1-299 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEDGKISKIGPENPYNTPV FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKQNKSVTVLDMGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI CQYVDDLYIASDLEIEQHRTKIKELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10F, V11I, L33F, Q58E, G73S, L89V | I13IV, K20R, E35D, M36I, N37Q, R57K, D60E, I62V, L63P, A71V, V77T, I93L |
| >CA68660| codons 1-99 PQITLWQRPFITVKIGGQLREALLDTGADDTIFEDIQLPGRWKPKIVGGIGGFLKVKEYE QVPIEICGHKVISTVLTGPTPVNVIGRNVMTQLGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E10D, I72V, L101I, K111T, T122I, K188R, V201I |
| >CA124176| codons 1-288 FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVTTIHTDNGSN FISTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRRGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |