Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1590 | CA68617 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 139 |
| 2 | AZT+DDC+IDV | 26 |
| 3 | D4T+DDC+IDV | 52 |
| 4 | 3TC+DDI+RTV+SQV | 22 |
| 5 | D4T+DDI+IDV+NFV | 58 |
| 6 | ABC+APV+NVP+RTV | 333 |
| 7 | ABC+FPV+NVP+RTV | 60 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219N | K101E, Y181C, M230L | E44D, V60I, K66R, V118I, K122E, I135T, G196E, T200I, E203K, Q207D, H208Y, R211K, K223E, L228R, A272P, T286TP |
| >CA68617| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKRNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRIKIKELRDYLWKWGFYTPDNKHQEEPPFRWLGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVIPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82L, L90M | L33F, G73T, L89V | L10I, V11L, T12E, I13V, L19M, M36I, R41K, L63P, A71V, V77I, I93L |
| >CA68616| codons 1-99 PQITLWQRPILEVKIGGQMKEALLDTGADDTVFEEINLPGKWKPKIIGGVGGFVKVRQYD QIPIEICGHKVITTVLIGPTPLNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |