Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7849 | CA68595 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 130 |
| 2 | ABC+APV+D4T+DLV | 65 |
| 3 | 3TC+ABC+D4T+LPV+SQV | 291 |
| 4 | 3TC+ABC+FTC+TDF | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67G, K219E | K103KN | V35IT, K43Q, S68G, T69A, S117SA, V118I, D121Y, K122E, I142V, R172RK, D177G, V179I, T200A, E203EA, H208Y, L210F, R211K, D218E, L228H, A272P, K277R, Q334L |
| >CA68595| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEQEGKISKIGPENPYNTPV FAIKKKGGARWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFAIPL YEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPGIII YQYVDDLYVGSDLEIGQHRAKIAELRQYLFKWGFFTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48M, I54V, V82T, I84V | K43T, F53L | L10I, K20R, E35D, M36I, I62V, L63P, I66F, A71V, Q92R |
| >CA68594| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWTPKMVMGIGGLVKVRQYD QVPIEFCGHKVIGTVLVGPTPTNVIGRNLLTRIGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D3E, E10D, I72V, L101I, M154L, D256E |
| >CA124155| codons 1-288 FLEGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESLNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |