Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3972 | CA68568 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT+IDV | 104 |
| 3 | AZT+D4T+SQV | 87 |
| 4 | 3TC+AZT+NFV | 48 |
| 5 | 3TC+AZT+IDV+RTV | 40 |
| 6 | ABC+APV+D4T | 67 |
| 7 | 3TC+EFV+IDV+RTV | 97 |
| 8 | 3TC+AZT+TDF | 57 |
| 9 | 3TC+ATV+RTV+TDF | 118 |
| 10 | ABC+FTC+RTV+T20+TDF+TPV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82L, L90M | Q58QE, T74P | L10I, I13V, K20I, L33V, E35D, M36I, N37T, I62V, L63P, I64IV, A71V, I93L |
| >CA68568| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVVEDITLPGRWKPKIIGGIGGFVKVREYD QVPVEICGHKVIGPVLVGPTPLNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219D | K101H | V35VI, K43E, T69TA, V118I, K122E, S162C, E169D, H208Y, R211K, D218E, V245M, T286A, I293V, Q334E, R358K, K366R | E40FL |
| >CA68569| codons 1-368 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTLLEEEGKISKIGPENPYNTPV FAIKKKNSAKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPEDKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVRQL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, K156N, A169V, T218S, L234H |
| >CA124198| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNNELKKIIGQVRDQVEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQISKIQNFRVYYRDSRDPHWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |