Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt245 | 1195MB | South Africa | 1999 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36L, N37S, R41K, L63P, H69K, L89M, I93L | D25G |
| >1195MB| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLGTGADDTVLEELSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6D, V35T, T39E, S48T, V60I, K122E, D123G, T139R, I142K, T165I, K173A, Q174K, D177E, T200A, R211K, F214L, V245Q, A272P, K277G, T286A, E291D, V292I, I293V, I329L, G335D, R356K, G359T, T377L, K390R, A400V, E404D, G436E, E449D, D460N, V466I, D471E, T477A, H483Q, S519N, K530R, A534S, A554K |
| >1195MB| codons 1-560 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNERPGKRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVGQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWEVWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVEAETFYVDGAANRDTKLGKAGYVTNRGRQKIVSLTETTNQKAELQ AIQLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E10D, D25E, V31I, F100Y, L101I, G106A, T112X, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A | S283G |
| >1195MB| codons 1-288 FLDGIDKAQDEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAARWPVKXIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |