Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt242 | 1184MB | South Africa | 1999 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36L, N37S, R41K, L63P, H69K, L89M, I93L |
| >1184MB| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEELSLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39R, S48T, K104E, K122E, D123N, S162C, K173A, D177E, T200A, Q207E, K238R, E248N, D250E, N255D, A272P, K275Q, K277R, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, I375V, T377I, K390R, E399D, A400T, E404D, V435I, L452I, S468T, D471E, H483Q, L491S, I495V, S519N, K530R, A534S, A554S |
| >1184MB| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICREMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKESVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDRWT VQPIVLPNKESWTVDDIQKLVGKLNWASQIYPGIQVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA HTNDVKQLTEAVQKVAIESIVIWGKTPKFRLPIQKETWDTWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKIGKAGYVTDRGRQKVVTLTETTNQKTELQ AIQLALQDSGSEVNVVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| E11D, S17N, D25E, S39N, M50I, I72V, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, V201I, T218I, L234I, D278A | S283G |
| >1184MB| codons 1-288 FLDGIDKAQEDHEKYHNNWRAMASEFNLPPVVAKEIVANCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |