<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt214 04SK191B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14N, L19I, M36I, L63V, H69K, T74S, L89M, I93L, C95R  
>04SK191B1| codons 1-99
PQITLWQRPLVTVNIGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGRTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, K122E, D123S, K126R, A158S, K173A, T200A, Q207E, V245Q, A272P, I274V, K275R, K277R, Q278N, T286A, E291D, I293V, K323R, Q334N, G335D, R356K, G359T, Q373R, I375M, T377M, T386I, K390R, E396D, A400T, E404D, E413D, V435A, K454N, R461K, S468T, D471E, T477A, H483Q, L491S, E514G, S519N, K527N, K530R, V531I, A534S, A554K F130L, F171V
>04SK191B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRRYTALTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPVRAQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGVRVRNLCKLLRGAKALTDVVPLTEEAE
LELAENREILKEPVHGVYYDPSRDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVRKMAMESIVIWGKIPKFRLPIQKDTWETWWTDYWQATWIPDWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGNAGYVTDKGRQKVVTLTETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSGSELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, K215R, R231G, L234I, K244E, D278A I36V, S283G, R284G
>04SK191B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEVVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQRQITKIQNFRVYYRDSGDPIWKGPAK
LLWEGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGGQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006