Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Pt214 | 04SK191B1 | South Africa | 2004 | HIV1 | C | Plasma | MC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14N, L19I, M36I, L63V, H69K, T74S, L89M, I93L, C95R |
| >04SK191B1| codons 1-99 PQITLWQRPLVTVNIGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGRTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, K122E, D123S, K126R, A158S, K173A, T200A, Q207E, V245Q, A272P, I274V, K275R, K277R, Q278N, T286A, E291D, I293V, K323R, Q334N, G335D, R356K, G359T, Q373R, I375M, T377M, T386I, K390R, E396D, A400T, E404D, E413D, V435A, K454N, R461K, S468T, D471E, T477A, H483Q, L491S, E514G, S519N, K527N, K530R, V531I, A534S, A554K | F130L, F171V |
| >04SK191B1| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRRYTALTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPVRAQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGVRVRNLCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPSRDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVRKMAMESIVIWGKIPKFRLPIQKDTWETWWTDYWQATWIPDWEFVNTP PLVKLWYQLEKEPIAGAETFYVDGAANRETKLGNAGYVTDKGRQKVVTLTETTNQKAELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSGSELVNQIIEQLINKERIYLSWVPAHK GIGGNEQVDKLVSKGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, L45Q, M50I, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, K215R, R231G, L234I, K244E, D278A | I36V, S283G, R284G |
| >04SK191B1| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAKEVVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQRQITKIQNFRVYYRDSGDPIWKGPAK LLWEGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGGQDED |
References
| Author | Title | Citation |
| Rousseau, CM | Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. | J Virol Methods, 2006 |