<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt212 04SK184B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19T, M36I, R41K, L63T, H69K, V82I, I93L  
>04SK184B1| codons 1-99
PQITLWQRPLVSIKVGGQTKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGTVLVGPTPINIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39E, S48T, V60I, K122A, K173T, Q174K, D177E, T200E, Q207E, R211K, V245Q, D250N, A272P, E291D, V292I, I293V, E297V, S322P, Q334D, G335D, R356K, M357R, G359A, T377Q, S379C, K390R, A400T, E404D, I434L, V435T, A437V, L452V, S468T, T470N, D471E, H483Q, L491S, K512S, S519N, Q524E, K530R, A534S, A554S  
>04SK184B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DADFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI
YQYMDDLYVGSDLEIGQHREKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKNSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTVEAE
LELAENREILKEPVHGVYYDPPKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRAA
HTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPLTGVETFYVDGAANRETKVGKAGYVTDRGRQKVVTLNETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDSSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  T66S V31I, M50T, I72V, P90S, F100Y, L101I, T112V, S119P, T124N, T125A, K136Q, V201I, I203M, T218I, I220V, L234I, R269K, D278A S283G
>04SK184B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEATHGQVDCSPGI
WQLDCSHLEGKVILVAVHVASGYIEAEVISAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSNAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQIIKVQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006