<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt153 04PS194MB1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        P4S, V35T, E36A, T39E, S48T, W88C, V118I, K122E, D123S, T165I, K166R, K173A, Q174K, V179I, T200A, Q207E, F214L, V245E, A272S, K275Q, T286A, E291D, V292I, I293V, Q334Y, R356K, G359A, V365I, K390R, E396G, E404D, K431Q, V435A, A437V, Y441C, L452M, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, K530R, V531I, A534S, A554K I180T
>04PS194MB1| codons 1-560
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIRILEPFRAKNPDIIT
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIQVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKNLKTGKYAKMRAA
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKGTWEAWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEQEPIAGVETFCVDGAANRETKMGKAGYVTDKGRQKIVSLTETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKERIYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, G16E, L19I, E35D, M36I, R41K, D60E, I66V, H69K, L89M, I93L  
>04PS194MB1| codons 1-99
PQITLWQRPLVTIKVEGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE
QILIEVCGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, K14R, S17N, D25E, V31I, L45Q, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, A265V, D278A S283G
>04PS194MB1| codons 1-288
FLDGIEKAQEEHERYHNNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006