<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt140 04PS161B1 South Africa 2004 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, K20R, E35D, M36I, P39S, R41K, K45R, Q61E, L63A, C67F, H69K, L89M, I93L  
>04PS161B1| codons 1-99
PQITLWQRPLVSIKVGGQVREALLDTGADDTVLEDINLSGKWKPRMIGGIGGFIKVRQYD
EIAIEIFGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        P4S, V35T, T39N, V60I, D123E, K166R, K173A, Q174K, D177E, G196E, T200A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, E291D, V292I, I293V, P294A, Q334H, R356K, G359T, T369V, T377I, K390R, E399D, A400I, E404D, E432D, L452M, R461K, V466I, S468T, D471E, H483Q, L491S, S519N, Q520N, K527N, K530R, A554R  
>04PS161B1| codons 1-560
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIEQHRAKVEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVALTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLVEAVQKIAIESIVIWGKTPKFRLPIQKETWDIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVDGAANRETKMGKAGYVTDKGRQKIVTLTETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNNIIEQLINKERVYLAWVPAHK
GIGGNEQVDKLVSRGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  E92G K14R, D25E, V31I, I60M, L101I, K111Q, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A S283G
>04PS161B1| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGM
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAGTGQETAYFILKLAGRWPVQVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006