<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt67 03PS125MB1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I13V, K14R, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93L  
>03PS125MB1| codons 1-99
PQITLWQRPLVSVRVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6K, V35T, E36G, T39E, S48T, V60I, K122E, D123S, S134G, I135V, S162Y, K173A, Q174K, D177E, T200A, Q207E, R211K, V245K, A272P, K275R, Q278N, T286A, E291D, V292I, D324E, G335D, R356K, M357R, G359T, T377M, K390R, A400T, E404D, I434M, V435A, G436E, A437V, L452I, S468T, D471E, T477A, H483Q, L491P, I495V, S519N, Q524E, K530R, A534S, A554S Y144D, T472P
>03PS125MB1| codons 1-560
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTGICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPGVNNETPGIRDQYNVLPQGWKGSPAIFQYSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKNLCKLLRGAKALTDIIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPMAEVETFYVDGAANRETKIGKAGYVTDRGRQKVVTLTEPTNQKAELQ
AIQLALQDSGPEVNVVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, D25E, V31I, M50I, I60V, F100Y, L101I, T112V, S119P, T125A, K136Q, V201I, E212V, T218I, K219Q, L234I, N254Q, D278A S283G
>03PS125MB1| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGV
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKVLQKQIIQIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDQSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006