<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt44 03PS083MB1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12A, I15V, L19V, M36I, R41K, L63T, H69K, V82I, L89M, I93L  
>03PS083MB1| codons 1-99
PQITLWQRPLVAIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V8I, V35K, T39E, S48T, K122E, K126R, K173A, Q197K, T200E, R211K, V245Q, A272P, K277R, T286V, E291D, V292I, I293V, Q334H, G335E, R356K, G359T, T369A, T377M, K390R, A400I, T403I, E404D, V435I, A437V, G444E, L452M, Y457H, V458I, S468T, D471E, Q480K, H483Q, L491S, S515P, S519N, K530R, A534S, A554S  
>03PS083MB1| codons 1-560
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALKEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRRYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDIVI
YQYMDDLYVGSDLEIGKHREKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGVKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHEQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLAEAVQKIAMESIVIWGKTPKFRLPIQKETWEIWWIDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIGVETFYVDEAANRETKMGKAGHITDRGRQKVVTLTETTNQKTELK
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSEPELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, S24N, D25E, M50I, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, D167E, V201I, T218I, L234I, D278A S283G
>03PS083MB1| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMANEFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006