<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Pt41 03PS077B1 South Africa 2003 HIV1 C Plasma MC

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, E35D, M36I, R41K, R57K, D60E, H69K, V82I, L89M, I93L  
>03PS077B1| codons 1-99
PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QILIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39E, S48T, V60I, V90I, V118I, K122E, T139K, I142K, T165I, K173A, I202V, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, L325S, Q334E, R356K, G359T, T377L, K390R, A400T, E404D, V435A, G436E, N447S, L452Q, V466I, V467I, S468P, D471E, T477A, H483R, L491S, S519N, Q520K, K527E, K530R, A534S, A554S  
>03PS077B1| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNEKPGKRYQYNVLPQGWKGSPAIFQSSMIKILEPFRAQNPDIVI
YQYMDDLYVGSDLEIGQHRTKVEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDSIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAEAETFYVDGAASRETKQGKAGYVTDRGRQKIIPLTETTNQKAELQ
AIRLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNKIIEQLIEKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S24C, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, K188R, V201I, T218I, L234I, A265V, R269K, D278A S283G
>03PS077B1| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMACEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRRGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

References
Author Title Citation
Rousseau, CM Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes. J Virol Methods, 2006